![]() ![]() The sensitivity of TIC compared with the final histopathological result, considered the gold standard, was 90% (CI, 68.49-98.81%). No false positive results for TIC and FS was identified. Intraoperative TIC and FS failed to show metastatic involvement in 10 examined lymph nodes from three patients. Results: One hundred SLNs were examined from 49 patients with invasive breast carcinoma with mean age of 45.29 ° 10.6 years. The sensitivities, specificities, positive and negative predictive values of TIC, FS and IHC for the detection of metastatic tumor in the SLNs were determined with the corresponding 95% confidence intervals (CIs). Analysis of the permanent tissue included evaluation of three-step sections of the lymph node by H&E and immunohistochemical (IHC) staining. Final pathologic evaluation was performed on the formalin-fixed, paraffin-embedded tissue sections. The cytological and frozen findings were compared and results were reported to the surgeon during operation. The TIC and subsequently frozen were stained using hematoxylin and eosin. Materials and Methods: A total of 100 consecutive SLN biopsies from 49 patients performed. The sensitivities and specificities of TIC with those of FS analysis and IHC were also compared. Immunohistochemistry for cytokeratin was used on permanent sections. Objectives: The aim of this study was to review our department's results with SLN biopsy using touch imprint and frozen section for intraoperative diagnosis of breast cancer metastasis. However, the sensitivity of these intraoperative modalities for detecting metastatic disease in SLNs is not equivalent to permanent histopathologic examination as a gold standard method. Touch imprint cytology (TIC), frozen section (FS), scrape cytology, or combination of these methods are used as intraoperative diagnostic methods. Comparing touch imprint cytology, frozen section analysis, and cytokeratin immunostaining for intraoperative evaluation of axillary sentinel lymph nodes in breast cancerĪkbar Safai 1, Ali Razeghi 1, Ahmad Monabati 1, Negar Azarpira 1, Abdolrasoul Talei 2ġ Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran 2 Department of Surgery, Shiraz University of Medical Sciences, Shiraz, IranĬlick here for correspondence address and email Date of Web Publicationīackground: Sentinel lymph node (SLN) biopsy has been applied to the management of breast carcinoma inorder to decrease postoperative complication and morbidity. ![]()
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